Topical N-acetyl-S-farnesyl-L-cysteine Inhibits Mouse Skin Inflammation, and Unlike Dexamethasone, its Effects Are Restricted to the Application Site
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چکیده
منابع مشابه
N-acetyl-L-cysteine inhibits marble-burying behavior in mice.
In the present study, we examined the effect of N-acetyl-L-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor...
متن کاملN-Acetyl L-Cysteine does not protect mouse ears from the effects of noise*
BACKGROUND Noise-induced hearing loss (NIHL) is one of the most common occupational injuries in the United States. It would be extremely valuable if a safe, inexpensive compound could be identified which protects worker hearing from noise. In a series of experiments, Kopke has shown that the compound N-acetyl-L-cysteine (L-NAC) can protect the hearing of chinchillas from the effects of a single...
متن کاملN-acetyl Cysteine N-acetyl Cysteine Inhibits Exercise-induced Lymphocyte Apoptotic Protein Alterations
PURPOSE: To investigate the effect of strenuous exercise and antioxidant administration on proand antiapoptotic protein expression in intestinal lymphocytes. METHODS: Female C57BL/6 mice (N = 52) were randomly assigned to receive N-acetyl cysteine (NAC; 1 g.kg(-1)) or saline (SAL) 30 min before treadmill exercise (EX) for 90 min and 2 degrees slope (30 min at 22 m.min(-1), 30 min at 25 m.min(-1...
متن کاملEffects of N-acetyl-L-cysteine on Postoperative Intrabdominal Adhesion in a Large Animal Model
Objective- Mechanisms that decrease oxidative stress and enhance peritoneal fibrinolysis reduce adhesions. N-acetyl-L-cysteine (NAC) is an antioxidant whose effect on peritoneal fibrinolysis in large animal model has not been established. The aims of this study were to investigate the ability of NAC to decreased adhesion in stablished model of serosal trauma in sheep. Design- Expe...
متن کاملThe synthesis of S-benzylthiopyruvic acid and its conversion to N-acetyl-S-benzyl-L-cysteine in the rat; unavailability of thiopyruvic acid to rats for growth purposes.
Some time ago we demonstrated the acetylation of S-benzyl-L-cysteine in the dog, rabbit, rat, and man (l-3). Administration of S-benzyl-ncysteine to rats (4, 5) or man (3) was followed by the excretion of some N-acetyl-S-benzyl-L-cysteine, thus indicating a partial inversion of the D derivative of cysteine to the optical antipode. Ample experimental evidence is available to show that oxidative ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2008
ISSN: 0022-202X
DOI: 10.1038/sj.jid.5701061